Question:medium
Drug of choice in laryngeal stenosis is:
Drug of choice in laryngeal stenosis is:
Show Hint
Stenosis is a scarring problem. Pick the topical antifibroblast agent.
Updated On: Jun 24, 2026
- Cyclophosphamide
- Doxorubicin
- Adriamycin
- Mitomycin C
Show Solution
The Correct Option is D
Solution and Explanation
The core issue in laryngeal stenosis is scar. After the airway is dilated or the scar is cut, fibroblasts rush back and lay down fresh collagen, so the narrowing returns. The ideal drug therefore is one that locally blocks fibroblasts.
Mitomycin C fits exactly. It is a streptomyces derived agent that alkylates DNA and powerfully inhibits fibroblast growth. Surgeons apply it topically on a soaked pledget to the freshly treated stenotic segment, which slows down scar reformation and improves the durability of dilation. That is its accepted role as the adjunct of choice in airway stenosis.
The other three options are systemic anticancer drugs. Cyclophosphamide is used for lymphomas and autoimmune disease, while doxorubicin and adriamycin are two names for the same anthracycline used in many solid and haematological cancers. None of them is placed topically to prevent airway scarring.
So the agent matched to the mechanism of stenosis is the one that locally curbs fibroblasts.
\[\boxed{\text{Mitomycin C}}\]
Mitomycin C fits exactly. It is a streptomyces derived agent that alkylates DNA and powerfully inhibits fibroblast growth. Surgeons apply it topically on a soaked pledget to the freshly treated stenotic segment, which slows down scar reformation and improves the durability of dilation. That is its accepted role as the adjunct of choice in airway stenosis.
The other three options are systemic anticancer drugs. Cyclophosphamide is used for lymphomas and autoimmune disease, while doxorubicin and adriamycin are two names for the same anthracycline used in many solid and haematological cancers. None of them is placed topically to prevent airway scarring.
So the agent matched to the mechanism of stenosis is the one that locally curbs fibroblasts.
\[\boxed{\text{Mitomycin C}}\]
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