Question:medium
Drug of choice for invasive aspergillosis is:
Drug of choice for invasive aspergillosis is:
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One triazole beat amphotericin B head-to-head and became first line.
Updated On: Jun 23, 2026
- Posaconazole
- Voriconazole
- Liposomal amphotericin B
- Caspofungin
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The Correct Option is B
Solution and Explanation
Clinical pearl: for invasive aspergillosis, the first move is a triazole, and the specific one is voriconazole, remembered as 'V for the Vessel-invading Aspergillus'.
Voriconazole earned its first-line spot after a controlled trial demonstrated better outcomes than amphotericin B deoxycholate. It works by inhibiting ergosterol biosynthesis, weakening the fungal membrane.
Sort the rest by role: liposomal amphotericin B is the principal alternative when voriconazole is contraindicated; caspofungin, an echinocandin acting on the cell wall, and posaconazole are reserved for salvage therapy or prophylaxis. That keeps voriconazole as the single best answer.
Voriconazole earned its first-line spot after a controlled trial demonstrated better outcomes than amphotericin B deoxycholate. It works by inhibiting ergosterol biosynthesis, weakening the fungal membrane.
Sort the rest by role: liposomal amphotericin B is the principal alternative when voriconazole is contraindicated; caspofungin, an echinocandin acting on the cell wall, and posaconazole are reserved for salvage therapy or prophylaxis. That keeps voriconazole as the single best answer.
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