To answer the question about which disease is caused by a deficiency of vitamin $B_1$, we first need to understand what vitamin $B_1$ is and its role in the body.
Vitamin $B_1$, also known as thiamine, is an essential nutrient that all tissues of the body need to function correctly. It plays a critical role in the body's energy metabolism and is also important for cellular processes. Thiamine is involved in the breakdown of carbohydrates, which is vital for providing energy to the body.
Now, let's analyze each option:
Based on the descriptions above, the correct answer is Beri-Beri, which is the disease caused by a deficiency of vitamin $B_1$. This condition is characterized by symptoms such as weakness, pain in the limbs, edema, and in severe cases, can lead to heart failure.
In conclusion, understanding the role of vitamins and their deficiencies is crucial in medical and general knowledge, especially for health-related professions and exams.