Question

De novo synthesis of purines, is not operative in
(A) Liver
(B) Erythrocytes
(C) Kidney
(D) Brain
Choose the correct answer from the options given below:

• A. (B) and (D) only.
• B. (A) and (C) only.
• C. (A), and (B) only
• D. (C) and (D) only.

Hint:

De novo purine synthesis is essential in many tissues except in erythrocytes and the brain where alternative pathways are utilized

Answer 1

The Correct Option is B

Erythrocytes and the brain do not perform de novo purine synthesis. This is because erythrocytes lack the necessary organelles, while the brain primarily uses the salvage pathway. In contrast, the liver and kidneys are involved in de novo purine synthesis.