Question

Cri du chat syndrome is associated with a deletion on which part of a chromosome?

• A. Chromosome 5q arm
• B. Chromosome 15p arm
• C. Chromosome 15q arm
• D. Chromosome 5p arm

Hint:

Cri du chat = 5p deletion = Short arm of chromosome 5.

Answer 1

The Correct Option is D

The question asks about the genetic association of Cri du chat syndrome, which is linked to a specific chromosomal deletion.

Cri du chat syndrome, also known as 5p− (5p minus) syndrome, is a genetic disorder resulting from a deletion of the short arm (p arm) of chromosome 5. It is a rare genetic condition characterized by a high-pitched crying sound similar to that of a cat, which is where it gets its name. Other symptoms may include intellectual disability, delayed development, small head size (microcephaly), and distinct facial features, among others.

Now, let's analyze the options given:

• Chromosome 5q arm: This refers to the long arm (q arm) of chromosome 5. Cri du chat syndrome is not associated with this part of the chromosome.
• Chromosome 15p arm: This refers to the short arm of chromosome 15. There is no known association of Cri du chat syndrome with chromosome 15.
• Chromosome 15q arm: Similar to the above, this option refers to the long arm of chromosome 15 and is unrelated to Cri du chat syndrome.
• Chromosome 5p arm: This is the correct part, as Cri du chat syndrome is linked to the deletion of this short arm of chromosome 5.

Therefore, the correct answer is: Chromosome 5p arm.

This deletion disrupts the normal development and function of the body, which leads to the various symptoms associated with the syndrome.