Question:medium

Corneal Transparency is maintained by which of the following GAGs

Updated On: Jun 23, 2026
  • Keratan Sulphate
  • Dermatan Sulphate
  • Heparan Sulphate
  • Chondroitin Sulphate
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The Correct Option is A

Solution and Explanation

Glycosaminoglycans (GAGs) are classified based on their sugar composition and sulfation pattern.

Keratan sulphate is unique among GAGs:
- Composition: N-Acetylglucosamine + Galactose (no uronic acid)
- First isolated from: Cornea
- Function in cornea: Maintains transparency by ensuring regular spacing of collagen fibrils in the stroma via proteoglycans (lumican, keratocan)

Comparison with other GAGs:
- Chondroitin sulphate: Glucuronic acid + N-Acetylgalactosamine -- found in cartilage
- Dermatan sulphate: Iduronic acid + N-Acetylgalactosamine -- found in skin
- Heparan sulphate: Glucuronic/Iduronic acid + Glucosamine -- found in basement membranes

Mnemonic: "Keratan Kornea Keeps Clarity"
\[\boxed{\text{Keratan Sulphate}}\]
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