Step 1: Trace the etymology of Obfuscate.
"Obfuscate" comes from Latin "ob" (over) + "fuscus" (dark); literally it means "to darken over" - and by extension to make something unclear, murky, or deliberately hard to understand.
Step 2: Eliminate antonyms from the options.
"Clarify" = to make clear (opposite); "Reveal" = to bring something hidden into the open (opposite); "Simplify" = to make easier (opposite); all three are antonyms.
Step 3: Select the correct synonym.
"Confuse" means to make unclear or puzzling - this is the closest synonym to "Obfuscate"; both words describe clouding or muddling someone's understanding.
\[ \boxed{\text{Confuse}} \]