Step 1: Understand the task.
We must add the right negative prefix to Possible to form its opposite.
Step 2: Recall the prefix rule.
The prefix in shifts to im before the bilabial letters p, b, or m to ease pronunciation.
Step 3: Check the base word.
Possible begins with p, a bilabial sound, so the im form is expected.
Step 4: Test the candidates.
Unpossible, Illpossible, and Inpossible are all invalid English words.
Step 5: Form the valid word.
Im plus Possible gives Impossible, a correct word meaning not able to happen.
Step 6: Conclude.
The correct prefix is Im, option B.
\[ \boxed{\text{B. Im}} \]