Question:medium
Choose the best method of diagnosis for the clinical sign represented in the image.
Choose the best method of diagnosis for the clinical sign represented in the image.
Show Hint
The corneal ring points to Wilson disease, so test the copper-carrying protein.
Updated On: Jun 24, 2026
- Serum copper
- Serum ceruloplasmin
- Karyotyping
- PCR
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: Recognise the eye finding - a brownish ring at the corneal margin from copper laid down in Descemet's membrane is the Kayser-Fleischer ring. Step 2: It points to Wilson's disease, where defective ATP7B copper transport leads to copper overload. Step 3: The single most useful listed laboratory marker is a low serum ceruloplasmin, since most circulating copper normally travels bound to this protein; its level falls in Wilson's disease and forms part of the diagnostic criteria. Step 4: Total serum copper can be misleading, and genetic tests such as karyotyping or PCR are not the first-line confirmation here, so ceruloplasmin is the answer.\[\boxed{\text{Serum ceruloplasmin}}\]
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