Question

Basement membrane is made up of

• A. no cell product of epithelial cell
• B. epidermal cell only and
• C. endodennal cell
• D. both

Answer 1

The Correct Option is A

The basement membrane is a thin, fibrous, extracellular matrix of tissue that separates the epithelium, mesothelium, and endothelium from underlying connective tissue. It plays a crucial role in supporting cell layers and is involved in various cellular functions like signaling and filtration.

The correct answer to the question is "no cell product of epithelial cell." Let's explore the elements that the basement membrane comprises:

1. Components of the Basement Membrane:
   • The basement membrane is primarily made up of two layers: the basal lamina and the reticular lamina.
   • The basal lamina consists mainly of glycoproteins like laminin and fibronectin, which provide structural support and influence cell behavior.
   • The reticular lamina is composed of collagen fibers, particularly Type III collagen.
2. Non-cellular Nature:
   • The basement membrane is essentially acellular, meaning it does not contain cells but is a product of epithelial cells.
   • Epithelial cells secrete the components like collagen and proteoglycans that form the basal lamina, but the basement membrane itself does not include the cellular content.

Considering the above points, the basement membrane is not made up of cells themselves but is rather a structured matrix synthesized by cells. Therefore, the option "no cell product of epithelial cell" is justified as the basement membrane is a matrix produced and maintained by epithelial cell secretions.

Ruling out the other options:

• "epidermal cell only and": While epidermal (a type of epithelial) cells contribute to the secretion, they do not form the basement membrane itself.
• "endodennal cell": Endodermal cells pertain more to the digestive lining and are not directly responsible for the basement membrane structure.
• "both": This option combines two incorrect interpretations and misses the concept of secretion products being the main component.