Assertion (A): Early human genome estimates suggested over 30,000 genes due to perceived system complexity. However, subsequent progress revealed a lower actual gene count than initially projected.
Reason (R): This explanation is accurate as *in silico* gene prediction methods are inherently unreliable, particularly for non-coding regions and shorter genes, leading to discrepancies between predicted and observed gene numbers.
Explanation: Both statements are true, and Reason (R) effectively explains Assertion (A), making (A) the correct choice.