Step 1: Plan.
We test the Assertion with a small numerical example. Then we judge the Reason from the dot product rule.
Step 2: Write the lines in vector form.
Put $y = t$. The first line becomes $(x, y, z) = (q, 0, s) + t\,(p, 1, r)$.
So the direction vector is $\vec{b}_1 = p\hat{i} + \hat{j} + r\hat{k}$.
Similarly the second direction vector is $\vec{b}_2 = p^{\prime}\hat{i} + \hat{j} + r^{\prime}\hat{k}$.
Step 3: Compute the dot product.
\[ \vec{b}_1 \cdot \vec{b}_2 = pp^{\prime} + 1 + rr^{\prime} \]
Perpendicular lines need this to be $0$. So we need $pp^{\prime} + rr^{\prime} = -1$.
Step 4: Test the Assertion with numbers.
Take $p = p^{\prime} = 1$ and $r = r^{\prime} = 0$. Then $pp^{\prime} + rr^{\prime} = 1$, as in the Assertion.
But $\vec{b}_1 \cdot \vec{b}_2 = 1 + 1 + 0 = 2 \neq 0$. The lines are not perpendicular.
So the Assertion is false.
Step 5: Judge the Reason.
The Reason says that $\vec{b}_1 \cdot \vec{b}_2 = 0$ gives perpendicular lines. This is the standard rule, so it is true.
Final Answer:
Assertion false, Reason true: option (D).
\[ \boxed{\text{(D)}} \]