Question

Assertion (A): Insulin can't be administered orally. Reason (R): The animal insulin causes side effects to man due to non-self antigens.

• A. Both (A) and (R) are true. (R) is correct explanation for (A)
• B. Both (A) and (R) are true. (R) is not correct explanation for (A)
• C. (A) is true. But (R) is false
• D. (A) is false. But (R) is true

Hint:

Insulin must be injected because the stomach would digest it as food.

Answer 1

The Correct Option is B

Step 1: Read both parts.
Assertion: Insulin cannot be given by mouth. Reason: Animal insulin causes side effects in humans because it acts as a non-self antigen.

Step 2: Check the Assertion.
Insulin is a protein. If swallowed, the digestive enzymes in the stomach and gut would break it down into small bits, so it would never work. That is why it is injected, not taken orally. The Assertion is true.

Step 3: Check the Reason.
Insulin taken from animals like pigs or cows is slightly different from human insulin. The body can treat it as a foreign (non-self) antigen and react to it, causing side effects. So the Reason is also true.

Step 4: Does the Reason explain the Assertion?
No. The real reason insulin cannot be taken by mouth is that digestion destroys the protein. The antigen problem of animal insulin is a separate issue and does not explain why oral intake fails.

Step 5: Combine.
Both statements are true, but the Reason is not the correct explanation of the Assertion.

Step 6: Conclusion.
Therefore the correct answer is "Both (A) and (R) are true. (R) is not correct explanation for (A)". \[ \boxed{\text{Both true, R not explanation}} \]