Question

Assertion (A): Acute gouty arthritis is a common side effect of pyrazinamide therapy.

Reason (R): Pyrazinamide can cause hyperuricemia.

• A. Both A and R are true and R is the correct explanation of A
• B. Both A and R are true but R is NOT the correct explanation of A
• C. A is true but R is false
• D. A is false but R is true

Hint:

Pyrazinamide blocks uric acid excretion, and high uric acid is what causes gout.

Answer 1

The Correct Option is A

Step 1: Confirm the Assertion from drug knowledge.
Among the standard anti tubercular drugs, pyrazinamide has a specific reputation for bringing on acute gout in some patients during treatment. This makes the Assertion a correct statement.

Step 2: Confirm the Reason from the same drug's action.
The drug's breakdown product competes with uric acid for excretion by the kidney tubules, so less uric acid leaves the body and blood levels rise. This rise in blood uric acid is what hyperuricemia means, so the Reason is also correct.

Step 3: Connect cause and effect.
Gout attacks happen when uric acid crystals build up in a joint, and that build up needs high blood uric acid in the first place. Since pyrazinamide's main way of causing gout is exactly by raising uric acid, the Reason is not just true, it is the actual explanation for the Assertion.

Step 4: Drop the remaining codes.
The code that keeps R true without it explaining A does not apply, since the mechanism is a direct chain. The codes that mark either statement false do not apply either, since both are pharmacologically sound.

Final Answer:
Both the Assertion and Reason are true, with the Reason correctly explaining the Assertion.