Question

Assertion (A): A patient of ADA-deficiency requires periodic or repeated infusion of genetically-engineered lymphocytes.
Reason (R): Lymphocytes are not immortal, but have life span.

• A. Both (A) and (R) are true and (R) is the correct explanation of (A).
• B. Both (A) and (R) are true, but (R) is not the correct explanation of (A).
• C. (A) is true, but (R) is false.
• D. (A) is false, but (R) is true.

Hint:

In ADA-deficiency, periodic infusion of modified lymphocytes is needed due to their limited lifespan unless permanent gene correction is done in stem cells.

Answer 1

The Correct Option is A

Step 1: ADA-deficiency results in immunodeficiency, for which gene therapy with engineered lymphocytes is a treatment. Therefore, Assertion (A) is accurate.
Step 2: Due to the limited lifespan of lymphocytes, repeated administration of the treatment is necessary—rendering Reason (R) true.
Step 3: The short lifespan of lymphocytes necessitates repeated infusions, indicating that (R) accurately explains (A).
Consequently, both (A) and (R) are valid, and (R) provides the correct explanation for (A).