Question:medium

Arrange the sequence of erythroid series. A. Basophilic erythroblast
B. Polychromatic erythroblast
C. Reticulocyte
D. Proerythroblast
E. Orthochromatic erythroblast

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An easy mnemonic: “Pro-BPO-R” → Proerythroblast, Basophilic, Polychromatic, Orthochromatic, Reticulocyte.
Updated On: Feb 19, 2026
  • D, A, B, E, C
  • D, B, A, C, E
  • D, A, B, C, E
  • D, A, E, B, C
Show Solution

The Correct Option is A

Solution and Explanation

Step 1: Recall the erythropoiesis stages.
Erythropoiesis is the bone marrow process of red blood cell (RBC) production, commencing with a proerythroblast and concluding with a mature RBC.
Step 2: First stage – Proerythroblast.
The proerythroblast, the earliest recognizable erythroid precursor, is large with a prominent nucleus and basophilic cytoplasm.
Step 3: Second stage – Basophilic erythroblast.
This cell is smaller than the proerythroblast and exhibits intensely basophilic cytoplasm due to abundant ribosomes.
Step 4: Third stage – Polychromatic erythroblast.
Cytoplasm at this stage displays mixed staining (blue and pink) as ribosomes decrease and hemoglobin production rises.
Step 5: Fourth stage – Orthochromatic erythroblast.
This cell is largely filled with hemoglobin; its nucleus becomes pyknotic and is eventually extruded.
Step 6: Fifth stage – Reticulocyte.
Post-enucleation, the cell is a reticulocyte, retaining some ribosomal RNA. Reticulocytes mature into RBCs in circulation.
Step 7: Conclusion.
The correct sequence of erythropoiesis is: Proerythroblast → Basophilic erythroblast → Polychromatic erythroblast → Orthochromatic erythroblast → Reticulocyte.
Final Answer:
\[ \boxed{\text{The correct sequence is (A) D, A, B, E, C.}} \]
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