Question

Arrange the following blood group systems in chronological order of their discovery.
A. ABO
B. Rh
C. MNSs
D. MN
Choose the correct answer from the options given below:

• A. A, B, C, D
• B. A, D, B, C
• C. B, A, D, C
• D. C, B, D, A

Hint:

Remember Karl Landsteiner is the key figure. He discovered ABO first (around 1900), then MN (late 1920s), and then Rh (1940). This covers the basic order of the three most famous systems. MNSs is an expansion of MN, so it must come after MN.

Answer 1

The Correct Option is B

Step 1: Concept Overview:
This question tests your knowledge of immunology and human genetics history, specifically the discovery timeline of major human blood group systems.
Step 2: Detailed Explanation:
Here's the discovery year for each blood group system:
- A. ABO: Discovered by Karl Landsteiner in 1901.
- D. MN: Discovered by Karl Landsteiner and Philip Levine in 1927.
- B. Rh: Discovered by Karl Landsteiner and Alexander S. Wiener in 1940.
- C. MNSs: Following the MN discovery, the S and s antigens were discovered, expanding it into the MNSs system in 1947 (by Walsh and Montgomery) and 1951 (by Levine et al.). Thus, MNSs was established after MN and Rh.
Step 3: Final Answer:
Chronological order of discoveries:
1. ABO (1901) - A
2. MN (1927) - D
3. Rh (1940) - B
4. MNSs (1947 onwards) - C
The correct sequence is A, D, B, C.