Question:medium
Antiendomysial antibody is used in the screening of?
Antiendomysial antibody is used in the screening of?
Show Hint
Link this antibody to a gluten driven small bowel disorder.
Updated On: Jun 24, 2026
- Myasthenia gravis
- Autoimmune hepatitis
- Coeliac disease
- Graves disease
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: The question pivots on which disease pairs with the anti-endomysial antibody. This antibody targets the endomysium of smooth muscle and is the serological signature of gluten sensitivity.
Step 2: Gluten triggers flattening of the small bowel villi and mucosal immune activation in coeliac disease. Because EMA testing carries very high sensitivity and specificity, it serves as an excellent screening marker, alongside tissue transglutaminase and antigliadin antibodies.
Step 3: Each distractor belongs to a different autoantibody. Myasthenia gravis links to acetylcholine receptor antibodies, autoimmune hepatitis to anti smooth muscle antibodies, and Graves disease to TSH receptor stimulating antibodies. None involve endomysium, so the answer is coeliac disease, managed by lifelong gluten avoidance.
\[\boxed{\text{Coeliac disease}}\]
Step 2: Gluten triggers flattening of the small bowel villi and mucosal immune activation in coeliac disease. Because EMA testing carries very high sensitivity and specificity, it serves as an excellent screening marker, alongside tissue transglutaminase and antigliadin antibodies.
Step 3: Each distractor belongs to a different autoantibody. Myasthenia gravis links to acetylcholine receptor antibodies, autoimmune hepatitis to anti smooth muscle antibodies, and Graves disease to TSH receptor stimulating antibodies. None involve endomysium, so the answer is coeliac disease, managed by lifelong gluten avoidance.
\[\boxed{\text{Coeliac disease}}\]
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