Question:easy
Antibodies most commonly seen in drug-induced lupus are:
Antibodies most commonly seen in drug-induced lupus are:
Show Hint
The drug-induced form is anti-dsDNA negative but strongly linked to one nuclear protein antibody.
Updated On: Jun 24, 2026
- Anti-ds DNA antibodies
- Anti-Sm antibodies
- Anti-Ro antibodies
- Antihistone antibodies
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: Build a serology map for drug-induced lupus. The two signature findings are a positive ANA and a positive antihistone antibody, paired with a conspicuously negative anti-dsDNA.
Step 2: Match each option to that map. The antihistone option lines up exactly as the most common antibody in DILE, especially after agents like procainamide and hydralazine.
Step 3: Reject the anti-dsDNA option because its presence shifts the diagnosis toward classic SLE, the opposite of drug-induced disease. Anti-Sm and anti-Ro are linked to SLE and Sjogren or subacute cutaneous lupus, not to the drug-induced form.
Step 4: So the antibody flagged most often in drug-induced lupus is the antihistone antibody, even though it can also occur in idiopathic SLE.
\[\boxed{\text{Antihistone antibodies}}\]
Step 2: Match each option to that map. The antihistone option lines up exactly as the most common antibody in DILE, especially after agents like procainamide and hydralazine.
Step 3: Reject the anti-dsDNA option because its presence shifts the diagnosis toward classic SLE, the opposite of drug-induced disease. Anti-Sm and anti-Ro are linked to SLE and Sjogren or subacute cutaneous lupus, not to the drug-induced form.
Step 4: So the antibody flagged most often in drug-induced lupus is the antihistone antibody, even though it can also occur in idiopathic SLE.
\[\boxed{\text{Antihistone antibodies}}\]
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