Question:medium
Amphotericin B toxicity can be lowered by:
Amphotericin B toxicity can be lowered by:
Show Hint
Lipid carriers steer amphotericin away from the kidney, cutting its main toxicity.
Updated On: Jun 24, 2026
- Giving it with glucose
- Decreasing the dose
- Using liposomal delivery systems
- Combining with flucytosine
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The Correct Option is C
Solution and Explanation
Amphotericin B is a powerful antifungal that earns its old nickname amphoterrible because it damages the kidneys, causes chills and fever during the drip, and lowers potassium. We need the option that cuts this harm while keeping the drug working.
The smartest pharmaceutical fix is to repackage the drug. Liposomal and lipid-complex versions wrap amphotericin inside fatty carriers. These carriers steer the drug toward fungal membranes and the body's macrophage system and away from kidney tubules, so the renal injury falls sharply. This lets clinicians even use larger doses with less harm, the ideal trade.
Looking at the other suggestions: mixing it in glucose only concerns infusion preparation and does nothing for organ toxicity. Simply cutting the dose does reduce side effects but at the cost of curing the infection, so it is not a real solution. Adding flucytosine gives a synergistic combination that may permit a lower amphotericin dose, yet flucytosine brings its own marrow suppression and is chosen for efficacy more than for safety.
$\therefore$ Liposomal delivery is the recognised way to lower amphotericin B toxicity.
\[\boxed{\text{Using liposomal delivery systems}}\]
The smartest pharmaceutical fix is to repackage the drug. Liposomal and lipid-complex versions wrap amphotericin inside fatty carriers. These carriers steer the drug toward fungal membranes and the body's macrophage system and away from kidney tubules, so the renal injury falls sharply. This lets clinicians even use larger doses with less harm, the ideal trade.
Looking at the other suggestions: mixing it in glucose only concerns infusion preparation and does nothing for organ toxicity. Simply cutting the dose does reduce side effects but at the cost of curing the infection, so it is not a real solution. Adding flucytosine gives a synergistic combination that may permit a lower amphotericin dose, yet flucytosine brings its own marrow suppression and is chosen for efficacy more than for safety.
$\therefore$ Liposomal delivery is the recognised way to lower amphotericin B toxicity.
\[\boxed{\text{Using liposomal delivery systems}}\]
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