Question:medium

Aminopterin is added in HAT medium to:

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Remember: \[ \text{Aminopterin} \rightarrow \text{Blocks } \textit{de novo} \text{ nucleotide synthesis} \]
• HAT medium is used in hybridoma selection.
• Only cells with a functional salvage pathway survive in HAT medium. \[ \text{HAT} = \text{Hypoxanthine + Aminopterin + Thymidine} \]
Updated On: Jun 6, 2026
  • Block the de novo pathway of nucleotide synthesis
  • Activate the de novo pathway of nucleotide synthesis
  • Block the salvage pathway of nucleotide synthesis
  • Activate the salvage pathway of nucleotide synthesis
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The Correct Option is A

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