Question:medium
All of the following statements about Fanconi's anemia are true, except:
All of the following statements about Fanconi's anemia are true, except:
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Think about how this inherited marrow failure syndrome is actually passed on.
Updated On: Jun 24, 2026
- Autosomal dominant inheritance
- Hypocellular bone marrow
- Congenital anomalies
- Usually normocytic or macrocytic cell morphology
Show Solution
The Correct Option is A
Solution and Explanation
Fanconi anemia is a genetic disorder of defective DNA repair that ends in aplastic anemia. To answer an except question, we look for the one statement that does not fit the disease.
The genetics first. The condition runs in families through an autosomal recessive pattern, with a rare X-linked form. A dominant pattern is simply not how this disease is transmitted, so the statement claiming autosomal dominant inheritance is the incorrect one we are hunting for.
Now confirm the rest. As marrow failure sets in, the marrow loses its cells and turns hypocellular, which makes that statement correct. The syndrome is classically tied to birth defects like absent or malformed thumbs, radial ray problems, low height, cafe au lait spots, and kidney anomalies, so the congenital anomalies statement is also correct. The red cell size tends toward normocytic or macrocytic, often with high HbF, making that statement correct as well.
Since every option except the inheritance one matches the disease, the inheritance claim is the outlier.
$$\boxed{\text{Autosomal dominant inheritance}}$$
The genetics first. The condition runs in families through an autosomal recessive pattern, with a rare X-linked form. A dominant pattern is simply not how this disease is transmitted, so the statement claiming autosomal dominant inheritance is the incorrect one we are hunting for.
Now confirm the rest. As marrow failure sets in, the marrow loses its cells and turns hypocellular, which makes that statement correct. The syndrome is classically tied to birth defects like absent or malformed thumbs, radial ray problems, low height, cafe au lait spots, and kidney anomalies, so the congenital anomalies statement is also correct. The red cell size tends toward normocytic or macrocytic, often with high HbF, making that statement correct as well.
Since every option except the inheritance one matches the disease, the inheritance claim is the outlier.
$$\boxed{\text{Autosomal dominant inheritance}}$$
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