Question:medium
All of the following are markers of acute kidney injury EXCEPT?
All of the following are markers of acute kidney injury EXCEPT?
Show Hint
One option is the acid form of an enzyme; the alkaline form is the real renal marker.
Updated On: Jun 24, 2026
- Clusterin
- Osteopontin
- Alanine aminopeptidase
- Acid phosphatase
Show Solution
The Correct Option is D
Solution and Explanation
Step 1: A growing list of biomarkers signals early tubular injury in acute kidney injury, allowing detection before serum creatinine rises. We must spot the one substance that does not belong to this group.
Step 2: Alanine aminopeptidase is a brush-border tubular enzyme that leaks with injury; clusterin and osteopontin are stress proteins upregulated in damaged tubules. All three are validated AKI markers, joining KIM-1, NGAL, IL-18, NAG, cystatin C and beta-2-microglobulin.
Step 3: Acid phosphatase, by contrast, is not recognised as a kidney injury marker, so it is the exception and option d is the answer.
Step 4: The trap lies in confusing acid phosphatase with alkaline phosphatase; it is the alkaline form that figures among renal tubular enzyme markers.
\[\boxed{\text{Acid phosphatase}}\]
Step 2: Alanine aminopeptidase is a brush-border tubular enzyme that leaks with injury; clusterin and osteopontin are stress proteins upregulated in damaged tubules. All three are validated AKI markers, joining KIM-1, NGAL, IL-18, NAG, cystatin C and beta-2-microglobulin.
Step 3: Acid phosphatase, by contrast, is not recognised as a kidney injury marker, so it is the exception and option d is the answer.
Step 4: The trap lies in confusing acid phosphatase with alkaline phosphatase; it is the alkaline form that figures among renal tubular enzyme markers.
\[\boxed{\text{Acid phosphatase}}\]
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