Question:medium
All are true about nesidioblastosis except:
All are true about nesidioblastosis except:
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Think of the leading cause of persistent neonatal hypoglycaemia.
Updated On: Jun 24, 2026
- Hypoglycemic episodes are seen
- Occurs in adults more than children
- Histopathology shows hyperplasia of islet cells
- Diazoxide is used for treatment
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The Correct Option is B
Solution and Explanation
Nesidioblastosis describes a diffuse beta-cell disorder of the pancreas in which insulin is poured out without normal feedback control. The dominant clinical picture is repeated low blood sugar, because the unchecked insulin keeps driving glucose down, so the statement about hypoglycaemic episodes holds true. Looking at the tissue, the gland shows islet-cell hyperplasia with beta cells appearing to bud from duct lining, confirming the histopathology statement. Treatment begins medically with diazoxide, an agent that opens potassium-ATP channels on the beta cell and shuts down insulin output, validating that option. The single statement that does not fit is the claim about age distribution. This is fundamentally a neonatal and infantile entity, the leading cause of persistent hypoglycaemia in newborns, and it is far more common in children than in adults. Hence the assertion that it occurs more in adults than children is the wrong statement.
\[\boxed{\text{Occurs in adults more than children}}\]
\[\boxed{\text{Occurs in adults more than children}}\]
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