Question

Adenoviruses are frequently used in gene delivery experiments. Their average genome size is 36,000 base pairs. Of their total DNA content, up to how much of the adenovirus genome can be replaced by foreign DNA?

• A. 5000 base pairs
• B. 15,000 base pairs
• C. 20,000 base pairs
• D. 30,000 base pairs

Hint:

Consider the capacity of adenoviral vectors for foreign DNA replacement in gene therapy.

Answer 1

The Correct Option is D

Adenoviruses are extensively used as gene therapy vectors, capable of carrying large foreign DNA segments. They can accommodate up to 30,000 base pairs of foreign DNA within their genome without losing infectivity or delivery effectiveness.