(a) Why does DNA replication occur within a replication fork and not in its entire length simultaneously?
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Solution and Explanation
DNA replication proceeds at a replication fork due to two primary factors:
- DNA polymerase directionality: This enzyme exclusively synthesizes new DNA strands by adding nucleotides in the 5’ to 3’ direction.
- Antiparallel DNA structure: The antiparallel orientation of the DNA double helix necessitates continuous replication on one strand (the leading strand) and discontinuous replication on the other strand (the lagging strand) at the replication fork.
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