Question:medium

A patient is admitted with history of overdose of warfarin. Prothrombin time is significantly prolonged and the patient has ecchymosis and haematemesis. Therapeutic choices should include 1. Vitamin K 2. Naloxone 3. Fresh frozen plasma 4. N-acetylcysteine. Select the correct answer using the codes given below: Codes:

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Eliminate the two drugs that treat completely unrelated poisonings first.
Updated On: Jul 16, 2026
  • 1 only
  • 1 and 3
  • 2 and 4
  • 1, 2 and 3
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The Correct Option is B

Solution and Explanation

The fastest way through this is to sort the four listed drugs into relevant and irrelevant before matching to a code.

  1. Vitamin K: relevant. It is the specific antidote that restores production of the clotting factors warfarin suppresses.
  2. Naloxone: irrelevant. It is the opioid-overdose reversal agent and has nothing to do with anticoagulant bleeding.
  3. Fresh frozen plasma: relevant. It supplies ready-made clotting factors for immediate control of active bleeding while vitamin K takes effect over several hours.
  4. N-acetylcysteine: irrelevant. It is the paracetamol-overdose antidote, unrelated to warfarin toxicity.

With naloxone and N-acetylcysteine eliminated, only vitamin K and fresh frozen plasma remain, matching code 1 and 3.

Correct answer: 1 and 3 (Vitamin K and Fresh frozen plasma)

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