Step 1: Differentiate.
From $S = at^2 + bt + 6$, velocity is $v = 2at + b$ and acceleration is $2a$, a constant.
Step 2: Apply the conditions.
At $t = 4$, at rest means $8a + b = 0$, so $b = -8a$. At $t = 4$, $S = 16$ gives $16a + 4b = 10$.
Step 3: Solve.
Substituting, $16a - 32a = 10$, so $a = -\dfrac{5}{8}$ and acceleration $= 2a = -\dfrac{5}{4}$ m/sec$^2$.
\[ \boxed{-\dfrac{5}{4}\ \text{m/sec}^2,\ \text{option 4}} \]