Question:medium

A manufacturer wishes to formulate a cough syrup complying to Indian Pharmacopeial standards. What should be the concentration of sugar in the syrup?

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- IP BP Syrup standard = $66.7\%\text{ w/w}$ (weight-in-weight). - USP Syrup standard = $85\%\text{ w/v}$ (weight-in-volume).
Updated On: Jul 4, 2026
  • $66.7\%\text{ w/v}$
  • $66.7\%\text{ w/w}$
  • $85\%\text{ w/v}$
  • $85\%\text{ w/w}$
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The Correct Option is B

Solution and Explanation

Understanding the Concept: Syrups are concentrated aqueous solutions of a sugar, typically sucrose. The specific concentration required for a solution to be self-preserving varies between different compendial standards. Compendial Comparison Framework:
Indian Pharmacopoeia (IP) British Pharmacopoeia (BP): Define Syrup (Simple Syrup) as a concentrated solution containing 66.7% w/w sucrose. This mass-to-mass ratio creates a high osmotic pressure that prevents microbial growth, rendering the solution self-preserving.
United States Pharmacopeia (USP): Defines simple syrup at a concentration of 85% w/v, which corresponds to approximately $64.74\%\text{ w/w}$. Since the prompt specifies Indian Pharmacopeial compliance, the concentration must be expressed as $66.7\%\text{ w/w}$.
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