Question

A karyotype of a human suffering from a certain disorder is given below:

Answer the following:

• [(a)] Identify the disorder.
• [(b)] Write the symptoms of the disorder.
• [(c)] Give reason for such a disorder.

Hint:

Down’s syndrome results from an extra chromosome 21. It’s a chromosomal numerical abnormality.

Answer 1

1. [(a)] The condition is identified as Down syndrome (Trisomy 21).
2. [(b)] Manifestations encompass:
   • Intellectual disability.
   • Reduced height.
   • A wide facial profile.
   • A grooved tongue.
   • Delayed physical development.
3. [(c)] This condition arises from trisomy of chromosome 21, a result of nondisjunction during gamete formation, which results in an additional chromosome 21.