Question

A girl child has had recurrent yeast and respiratory virus infections since she was 3 months old. Now considering studies for immune status, which vaccine is contraindicated?

• A. TT/Td
• B. Measles/MMR
• C. DPT
• D. Killed IPV

Hint:

Identify whether the child is immunocompromised, then recall which vaccine types are contraindicated in immunodeficiency states.

Answer 1

The Correct Option is B

Clinical reasoning: Recurrent yeast (fungal) and viral respiratory infections since 3 months of age suggest a primary immunodeficiency, most likely SCID (Severe Combined Immunodeficiency) or a combined T- and B-cell defect.

General rule: Live vaccines are contraindicated in immunocompromised patients because the attenuated organism can replicate unchecked and cause overt disease.

Vaccine classification:
- TT/Td: Inactivated toxoid -- safe
- MMR (Measles/Mumps/Rubella): Live attenuated -- contraindicated
- DPT: Inactivated (diphtheria/tetanus toxoids + killed pertussis) -- safe
- Killed IPV: Inactivated polio vaccine -- safe

Other live vaccines contraindicated in immunocompromised individuals include BCG, oral polio vaccine (OPV), varicella vaccine, yellow fever vaccine, and rotavirus vaccine.

\[\boxed{\text{Measles/MMR (live attenuated vaccine)}}\]