Question:medium
A drug acting on potassium (K+) channels includes which of the following?
A drug acting on potassium (K+) channels includes which of the following?
Show Hint
Find the antianginal K+ channel opener with an NO-donor action.
Updated On: Jun 23, 2026
- Spironolactone
- Amiloride
- Nicorandil
- Methyldopa
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: Tag each option with its true target and keep only the potassium-channel one.
Step 2: Nicorandil opens ATP-sensitive K+ channels in cardiac muscle, hyperpolarizing the cell, dilating coronary vessels and mimicking ischemic preconditioning; its extra NO-donor action adds venodilation. This is the classic K+ channel opener of the antianginal group.
Step 3: Spironolactone works at the aldosterone receptor, amiloride plugs the ENaC sodium channel, and methyldopa is converted centrally to a false transmitter acting on alpha-2 receptors. All three bypass potassium channels.
Step 4: The single potassium-channel agent stands out.
\[\boxed{\text{Nicorandil}}\]
Step 2: Nicorandil opens ATP-sensitive K+ channels in cardiac muscle, hyperpolarizing the cell, dilating coronary vessels and mimicking ischemic preconditioning; its extra NO-donor action adds venodilation. This is the classic K+ channel opener of the antianginal group.
Step 3: Spironolactone works at the aldosterone receptor, amiloride plugs the ENaC sodium channel, and methyldopa is converted centrally to a false transmitter acting on alpha-2 receptors. All three bypass potassium channels.
Step 4: The single potassium-channel agent stands out.
\[\boxed{\text{Nicorandil}}\]
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