Step 1: Draw the signal flow graph nodes.
Call the reference $R$, the error node $E$, the forward output $C$, the second block's output $D$, and the inner summing node output $F$, which feeds back to the error node.
Step 2: Write the branch gains.
$E$ to $C$: gain $\dfrac{1}{s+4}$. $E$ to $D$: gain $\dfrac{1}{s+4}$, since the second block taps the same node $E$, not $C$. $C$ and $D$ combine at the inner summer as $F=C-D$. Finally $E=R-F$.
Step 3: Substitute to collapse the inner loop.
Since both $C$ and $D$ equal $E\cdot\dfrac{1}{s+4}$, we get $F=E\cdot\dfrac{1}{s+4}-E\cdot\dfrac{1}{s+4}=0$ identically, for any $E$.
Step 4: Reduce the graph.
With $F\equiv0$, the feedback branch carries no signal at all, so effectively there is no loop; the loop gain of this inner loop is zero and Mason's gain formula reduces to just the forward path from $R$ to $E$ to $C$.
Step 5: Write the forward path gain.
$E=R$, since $F=0$, and $C=E\cdot\dfrac{1}{s+4}=\dfrac{R}{s+4}$.
Step 6: State the transfer function.
\[ \frac{C(s)}{R(s)}=\frac{1}{s+4} \] \[ \boxed{\dfrac{1}{s+4}} \]